Abstract
ObjectiveThe objective of this study was to test the hypothesis that p53 Arg72Pro polymorphism may contribute to an increased risk of cutaneous melanoma (CM).MethodsBy searching the databases of PubMed, EMBASE, and Web of Science, a total of 8 eligible case-control studies with 1,957 CM cases and 2,887 controls were included in this meta-analysis. Stata software was used to analyze all the statistical data.ResultsThe pooled data by a fixed-effects model suggested an increased risk of CM associated with p53 Arg72Pro polymorphism under the genetic model of Arg/Pro vs. Pro/Pro without heterogeneity (ORArg/Pro vs. Pro/Pro = 1.76, 95% CI = 1.55-1.99, P heterogeneity = 0.075). A similar trend was seen in subgroups of hospital-based studies and population-based studies.ConclusionOur meta-analysis based on all studies shows that the p53 Arg72Pro polymorphism may increase individual susceptibility to CM, particularly in Caucasians and could serve as a biomarker to predict the population at high risk of CM.
Highlights
Cutaneous melanoma (CM) representing one of the most malignant skin cancers has caused a large number of skin cancer-related deaths, approximately 8,700 deaths in 2010 [1]
The pooled data by a fixed-effects model suggested an increased risk of CM associated with p53 Arg72Pro polymorphism under the genetic model of Arg/Pro vs. Pro/Pro without heterogeneity (ORArg/Pro vs. Pro/Pro = 1.76, 95% confidence interval (CI) = 1.55-1.99, Pheterogeneity = 0.075)
Our meta-analysis based on all studies shows that the p53 Arg72Pro polymorphism may increase individual susceptibility to CM, in Caucasians and could serve as a biomarker to predict the population at high risk of CM
Summary
Cutaneous melanoma (CM) representing one of the most malignant skin cancers has caused a large number of skin cancer-related deaths, approximately 8,700 deaths in 2010 [1]. The incidence rate steadily rises, with an average increase by 3–7% throughout the past decades among European populations [2]. It has generally been accepted that exposure to ultraviolet (UV) radiation is a main cause of skin cancer [3]. Epidemiological evidence has documented genetic variations in cancer-related genes are major contributing factors for this. P53 Polymorphism and Cutaneous Melanoma Risk malignancy [4,5]. The pathogeneses of this disease remains unclear
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