Abstract
ObjectivesFibromyalgia has seldom been associated with coronary heart disease (CHD). The aim of this study was to evaluate the risk of CHD in patients with fibromyalgia.MethodsWe used a dataset of one million participants, systemically scrambled from the Taiwanese national insurance beneficiaries, to identify 61,612 patients with incident fibromyalgia (ICD-9-CM 729.0–729.1) and 184,834 reference subjects matched by sex, age and index date of diagnosis in a 1:3 ratio from 2000 to 2005, with a mean 8.86 ± 2.68 years of follow-up until 2011. Risk of CHD was analyzed by Cox proportional hazard modeling.ResultsPatients with fibromyalgia had a mean age of 44.1 ± 16.5 years. CHD events developed in fibromyalgia patients (n = 8,280; 15.2 per 103 person-years) and reference subjects (n = 15,162; 9.26 per 103 person-years) with a significant incidence rate ratio of 1.64 (95% confidence interval: 1.61–1.68). The adjusted hazard ratio for CHD in fibromyalgia patients relative to reference subjects was 1.47 (1.43–1.51), after adjusting for age, gender, occupation, monthly income, traditional cardiovascular comorbidities, depression and anxiety. We noted that fibromyalgia and cardiovascular comorbidities had a significant interaction effect on CHD risk (p for interaction <0.01), which was markedly enhanced in fibromyalgia patients with concomitant comorbidities relative to patients with primary fibromyalgia and reference subjects (no fibromyalgia, no comorbidity).ConclusionsOur report shows that fibromyalgia patients have an independent risk for CHD development. Fibromyalgia patients with concomitant comorbidities have markedly increased CHD risk relative to those with primary fibromyalgia.
Highlights
Fibromyalgia is a syndrome with a broad spectrum of symptoms, including chronic widespread pain, non-restorative sleep, overwhelming fatigue, emotional swings, and cognitive dysfunction, with impaired daily social function and life quality [1]
coronary heart disease (CHD) events developed in fibromyalgia patients (n = 8,280; 15.2 per 103 person-years) and reference subjects (n = 15,162; 9.26 per 103 person-years) with a significant incidence rate ratio of 1.64 (95% confidence interval: 1.61–1.68)
We noted that fibromyalgia and cardiovascular comorbidities had a significant interaction effect on CHD risk (p for interaction
Summary
Fibromyalgia is a syndrome with a broad spectrum of symptoms, including chronic widespread pain, non-restorative sleep, overwhelming fatigue, emotional swings, and cognitive dysfunction, with impaired daily social function and life quality [1]. This syndrome involves pain patterns described as hyperalgesia and allodynia, but evidence is still insufficient to support fibromyalgia as an inflammatory or neuropathic disease [2]. The recent population-based studies using the modified 2010 classification criteria of American College of Rheumatology [11] reported a higher prevalence (~5–7%) of fibromyalgia [12, 13]. Fibromyalgia is second to osteoarthritis as the most common condition [14]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
