Abstract
This study compared the risk of chronic periodontitis (CP) between chronic rhinosinusitis (CRS) and non-chronic rhinosinusitis (control) patients using a national cohort dataset from the Korean Health Insurance Review and Assessment Service. CRS (n = 5951) and control participants (n = 23,804) were selected after 1:4 ratio matching for age, sex, income, region of residence, and preoperative CP visits. Postoperative CP visits were measured between 2002 and 2015. The margin of equivalence of the difference between the CRS and control groups was set between −0.5 and 0.5. Statistical significance was noted in the post-index date (ID) of the third, fourth, and fifth year periods. In subgroup analyses according to age and sex, statistical significance was observed in 40–59-year-old males in post-ID third, fourth, and fifth year periods, ≥60-year-old males in post-ID third and fourth year periods, and ≥60-year-old females in post-ID fifth year period (p < 0.05, each). In another subgroup analysis based on the number of pre-ID CP visits, statistical significance was observed for pre-ID CP (0 time) in the third, fourth, and fifth year periods (p < 0.05, each). This study revealed that CRS participants were likely to receive CP diagnosis and treatment.
Highlights
Chronic rhinosinusitis (CRS) is one of the most prevalent diseases of the upper respiratory tract
Sex, income, and region of residence were similar in the CRS and control groups (p = 1.000), while smoking and Charlson comorbidity index (CCI) scores were different between both groups (p < 0.05, Table 1)
This study revealed an increased risk for chronic periodontitis (CP) in post-index date (ID) three, four, and five-year periods following a diagnosis of CRS
Summary
Chronic rhinosinusitis (CRS) is one of the most prevalent diseases of the upper respiratory tract. The prevalence of adult CRS in the Korean population was 8.4% in a study analyzing five-year cross-sectional data from the Korean National Health and Nutrition Examination Survey [1]. European position paper on rhinosinusitis (EPOS) 2012 defined CRS as an inflammation of the nose and paranasal sinuses characterized by two or more symptoms, one of which should be either nasal blockage/obstruction/congestion or nasal discharge (anterior/posterior nasal drip): ± facial pain/pressure ± reduction or loss of sense of smell [3]. CRS is considered a chronic inflammatory disease rather than infection, wherein commensal resident microbiota and pathogenic microbiota could play a crucial role in the initiation and progression of the mucosal inflammation [5,6]
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