Abstract
BackgroundThe risk of acute pancreatitis in patients on long-term peritoneal dialysis is higher as compared to the general population. However, the relationship between long-term hemodialysis and acute pancreatitis has never been established.ObjectivesWe investigated the incidence of acute pancreatitis among patients on long-term hemodialysis in Taiwan to evaluate if there is a higher risk of acute pancreatitis in comparison to the general population.MethodsWe utilized a National Health Insurance (NHI) claims data sample containing one million beneficiaries. We followed all adult beneficiaries from January 1, 2007 until December 31, 2010 to see if they had been hospitalized for acute pancreatitis during this period. We further identified patients on chronic hemodialysis and compared their risk of acute pancreatitis with the general population.ResultsThis study included 2603 patients with long-term hemodialysis and 773,140 patients without hemodialysis. After controlling for age, gender, Charlson Comorbidity Index Score, geographic region, socioeconomic status and urbanization level, the adjusted hazard ratio was 3.44 (95% Confidence interval, 2.5–4.7).ConclusionsThe risk of acute pancreatitis in patients on long-term hemodialysis is significantly higher in comparison to the general population.
Highlights
Pancreatic abnormalities are commonly reported in chronic hemodialysis (HD) at postmortem autopsies [1,2]
The risk of acute pancreatitis in patients on long-term hemodialysis is significantly higher in comparison to the general population
At the end of follow-up, 2173 patients had been admitted for first-attack acute pancreatitis (AP), with 41 patients in the chronic HD group and 2132 without chronic HD
Summary
Pancreatic abnormalities are commonly reported in chronic hemodialysis (HD) at postmortem autopsies [1,2]. The high prevalence of pancreatic pathology after long-term dialysis hypothesized to some that dialysis might be a risk factor of acute pancreatitis (AP). While patients receiving peritoneal dialysis (PD) were found to have a higher risk of obtaining AP in comparison to the general population [3,4,5,6], studies evaluating the incidence of AP in HD patients have been inconclusive. The risk of acute pancreatitis in patients on long-term peritoneal dialysis is higher as compared to the general population. The relationship between long-term hemodialysis and acute pancreatitis has never been established
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