Abstract
BackgroundRecent studies suggest a role for hyperlipidemia in the development of diabetes. The aim of this study is to analyze the relationship between variations of total cholesterol (TC) levels and the risk for type 2 diabetes development from a Korean nationwide population-based database.Materials and methodsWe examined the General Health Check-up sub-dataset of the Korean National Health Insurance Service (NHIS) of 2,827,950 participants who had at least three health check-ups between 2002 and 2007, and were not reported to have diabetes during that time. The variations of TC levels between the examinations were calculated as follows: . The examinees were divided into 10 groups according to TC variation, and the hazard ratio for diabetes development from 2007 to 2013, were analyzed.ResultsDuring the follow-up period, 3.4% of the participants had developed diabetes. The hazard ratio (HR) for diabetes development relative to the overall risk in the whole study population started to be higher than 1.0 from eighth decile of TC variation. The highest decile group showed an increased HR for diabetes development after adjustment for confounding variables (1.139; 95% confidence interval 1.116~1.163). These results were similar regardless of the use of anti-hyperlipidemic medication and baseline TC levels.ConclusionsThe participants with a large variation in TC levels showed an increased risk for diabetes development, independent of the use of anti-hyperlipidemic medications. These results suggest a relationship between fluctuations in lipid levels and the development of type 2 diabetes.
Highlights
According to the 7th Diabetes Atlas released in 2015, 415 million people globally are suffering from diabetes [1]
The participants with a large variation in total cholesterol (TC) levels showed an increased risk for diabetes development, independent of the use of anti-hyperlipidemic medications. These results suggest a relationship between fluctuations in lipid levels and the development of type 2 diabetes
Type 2 diabetes is known to be a strong determinant for cardiovascular disease, because hyperglycemia and insulin resistance cause atherosclerosis through chronic activation of the diacylglycerol-protein kinase C (DAG-PKC) pathway, which has been associated with vascular abnormalities [3]
Summary
According to the 7th Diabetes Atlas released in 2015, 415 million people globally are suffering from diabetes [1]. More serious aspect is that the number will steadily increase in the future reaching 642 million patients worldwide in 2040. These observations are prominent in AsiaPacific region, which contains two-thirds of world’s population [2]. Multiple risk factors for cardiovascular disease (CVD) are accompanied in patients with diabetes, such as dyslipidemia, hypertension and coagulopathy. Glucose control, and multifactorial intervention for dyslipidemia and hypertension is needed to prevent vascular complications in patients with diabetes [4,5]. The aim of this study is to analyze the relationship between variations of total cholesterol (TC) levels and the risk for type 2 diabetes development from a Korean nationwide population-based database.
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