Increased reporting of subjective cognitive complaints over time predicts cognitive decline and incident dementia.

Abstract

Subjective cognitive complaints (SCCs) are a risk factor for dementia; however, little is known about their trajectories. Participants were 873 older adults (mage=78.65 years; 55% females) from the Sydney Memory and Ageing Study that were followed-up biennially. SCCs were measured using the six-item Memory Complaint Questionnaire. Associations between initial level of SCC reporting, linear change in SCC reporting, and change in global cognition over 6years was examined using latent growth curve analysis. Risk of dementia was examined over 10years using Cox regression. After controlling for demographics, mood and personality, results revealed a negative longitudinal association between the slope of SCCs and the slope of global cognition scores (b=-0.01, p=0.005, β=-0.44), such that participants who reported increasing SCCs showed a steeper rate of decline in global cognition over 6years. Cox regression also revealed participants who reported increasing SCCs had a nearly fourfold increased risk of developing dementia over 10years (hazard ratio 3.70, 1.24-11.01). This study explored whether initial levels of, and change in, SCCs over time are associated with both cognitive decline and risk of dementia. These findings are clinically relevant as GPs should note patients reporting increasing SCCs as they may be at greater risk of cognitive decline and incident dementia.