Abstract
The present experiments demonstrate high affinity stereospecific binding of the dopaminergic ligand [ 3H]spiroperidol to rat membranes. The binding was saturable, regionally distrubuted, and showed the same specificity as the caudate [ 3H]spiroperidol site for displacement by dopaminergic antagonists. Since there is an association between hypertension and abnormalities of renal blood flow, which appears to be regulated in part by dopamine, [ 3H]spiroperidol binding was measured in kidneys of spontaneously hypertensive rats. In two independent experiments renal cortical [ 3H]spiroperidol stereospecific binding was increased in spontaneously hypertensive rats.
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