Abstract
The effects of thioproperazine (TZ) pretreatment on 3H-DA synthesis and release were examined by measuring the simultaneous accumulation of 3H-DA in tissues and incubating medium after incubation of isolated cut striatum with 3H-tyrosine. TZ treatment in intact animals produced an almost immediate sustained increase in the synthesis of 3H-DA; this effect was associated with a markedly enhanced release of newly synthesized 3H-amine. Various data suggest that the drug indirectly activates nigro-striatal DA containing neurons through “DA receptor blockade”. TZ added directly onto isolated striatum did not affect release or synthesis of 3H-DA. TZ potentiated amphetamine induced release of 3H-DA but it blocked the other pharmacological effects of amphetamine occurring in animals.
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