Abstract
Background. The receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that has been considered to play a crucial role in tumor progression by enabling cancer cells to evade immune surveillance. The present study aimed to evaluate the clinical significance of the RCAS1 expression in gastric adenocarcinoma. Material and Methods. RCAS1 protein expression was assessed immunohistochemically on 54 gastric adenocarcinoma tissue samples and was analyzed in relation to clinicopathological parameters, tumor proliferative capacity, and patients' survival. Results. Enhanced RCAS1 expression levels were significantly associated with advanced histopathological stage and presence of organ metastasis (P = 0.0084 and P = 0.0327). Gastric cancer patients with elevated RCAS1 expression levels showed significantly shorter survival times compared to those with low RCAS1 expression (log-rank test, P = 0.0168). In multivariate analysis, histopathological stage and grade of differentiation as well as the RCAS1 expression were identified as independent prognostic factors (Cox regression analysis, P = 0.0204, P = 0.0035, and P = 0.0081). Conclusions. Our data support the evidence that RCAS1 upregulation may contribute to gastric malignant progression, representing a useful biomarker to predict the biological behaviour and prognosis in gastric neoplasia.
Highlights
The receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that has been considered to play a crucial role in tumor progression by enabling cancer cells to evade immune surveillance
In cross-tables, high RCAS1 expression was significantly more frequently observed in gastric adenocarcinoma cases with advanced histopathological stage and presence of organ metastasis (Table 1, P = 0.0327 and P = 0.0084, resp.)
The present study further showed that RCAS1 expression was significantly elevated in gastric cancer patients with advanced histopathological stage and presence of organ metastasis
Summary
The receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that has been considered to play a crucial role in tumor progression by enabling cancer cells to evade immune surveillance. The receptor-binding cancer antigen expressed on SiSo cells (RCAS1) was initially recognized by the mouse monoclonal antibody, 22-1-1, which was raised by the immunization of mice with the human uterine cervical adenocarcinoma cell line SiSo [1]. It is a 40-kd type II membrane protein that forms homo-oligomers through its C-terminal coiledcoil structures, whereas it exists in the soluble form probably by alternative splicing [2]. Several inflammatory mediators have been associated with tumor progression, angiogenesis, and metastasis in gastric cancer [11, 12]
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