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Abstract
Prostaglandin E 2 (PGE 2)- and 6-keto-PGF 1α-like immunoactivity was measured in incubates of forestomach and gastric corpus mucosa in (a) unoperated rats, (b) rats with sham-operation of the kidneys and (c) rats with bilateral nephrectomy. In addition the mean ulcer area in the forestomach and gastric mucosa was assayed in all three groups of rats. The PGE 2- and 6-keto-PGF 1α-like immunoactivity in gastric mucosa incubates and 6-keto-PGF 1α in the forestomach incubates was almost the same in unoperated and sham-operated rats. Increased 6-keto-PGF 1α in the forestomach and of PGE 2 and 6-keto-PGF 1α in the gastric mucosa was found in rats with bilateral nephrectomy before gastric lesions were seen. A higher mean ulcer area occurred in the forestomach and gastric mucosa 24–48 h after bilateral nephrectomy. We conclude, that the increased PGE 2- and 6-keto-PGF 1α production by the gastric mucosa and forestomach was associated with the loss of normal renal tissue function. Despite the protection of PGE 2 and PGI 2 by gastric tissue, gastric lesions nevertheless occur in acute uraemic rats.
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