Abstract
Background and objective: It has been demonstrated that progranulin (PGRN) is a neurotrophic factor that enhances neuronal survival and axonal growth. Several lines of evidence have indicated that PGRN plays a role in the pathomechanism of amyotrophic lateral sclerosis (ALS). So far studies of ALS skin have shown unique pathological and biochemical abnormalities. The lack of bedsore formation in ALS patients is considered characteristic. However, there has been no study of PGRN in ALS skin.
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