Increased production of triglyceride-rich lipoproteins after partial biliary diversion in the rhesus monkey

Abstract

An interrelationship between bile acid and triglyceride metabolism is suggested by observations in patients with endogenous hypertriglyceridemia and in subjects treated with bile acid-binding resins or chenodeoxycholic acid. We investigated this possible interrelationship in the rhesus monkey. The effect of 14 days of partial bile diversion on plasma concentration and secretion rates of triglyceride-rich lipoproteins was studied by means of a stream-splitting device that permitted controlled interruption of the enterohepatic circulation. Diversion of 25% of the enterohepatic circulation resulted in increased bile acid synthesis and decreased bile acid secretion and pool size, and was associated with a 75% increase in fasting serum triglyceride concentration and a twofold increase in the rate of secretion of triglyceride-rich lipoproteins into plasma. Intraduodenal replacement of cholic acid during the period of bile diversion completely prevented the increase in lipoprotein secretion and partially prevented the increase in fasting plasma triglycerides, suggesting that these changes resulted from loss of bile acid rather than other components of bile. These studies show that partial removal of bile acids from the enterohepatic circulation augments the secretion of triglyceride-rich lipoprotein into plasma in the rhesus monkey. Elucidation of the mechanism of this effect may provide important new information concerning the control of hepatic lipoprotein secretion.