Abstract
Cardiovascular disease (CVD) is a major cause of death around the world, with highest prevalence reported in minority Roma/Gypsy populations living in developed countries. Whether these differences are caused by unhealthy lifestyles or genetic factors remain unknown. The aim of our study was to examine the genotype frequencies of the rs10757274 polymorphism in the 9p.21 locus within ANRIL (antisense non-coding RNA in the INK4 locus), a long non-coding RNA located in the vicinity of the CDKN2A/2B inhibitors loci. ANRIL is understood to be the strongest genetic determinant of CVD in Caucasians. Using PCR-RFLP, we analysed the ANRIL rs10757274 polymorphism in 298 non-Roma (50% male) and 302 Roma/Gypsy (50% male) adult (39.5 ± 15.1 years and 39.2 ± 12.8 years, respectively) subjects. We found that frequencies of the ANRIL GG, GA and AA genotypes were 20.1%, 52.4% and 27.5% in the majority population and 32.9%, 47.9% and 19.2% in Roma/Gypsy subjects, respectively. The distribution of genotypes was deemed significantly different at P < 0.001. Within the Roma/Gypsy population, we detected increased prevalence of the CVD-associated GG genotype. Increased prevalence of CVD among Roma/Gypsies subjects may be significantly linked to genetic background.
Highlights
Cardiovascular diseases and myocardial infarction (CVD, MI) are the major causes of death in industrial countries
Previous publications on this topic are sparse and typically characterised by low numbers of examined subjects and non-representative selections, they report that prevalence of CVD risk factors in Roma/Gypsy communities is higher than in majority populations (Dobranici et al, 2012)
The question remains whether increased prevalence of CVD is caused not just by unhealthy lifestyles and by genetic factors, as genetic differences between Roma/Gypsy and non-Roma populations have been widely documented (Mydlárová Blaščáková et al, 2017; Hubacek et al, 2017, 2020; Nagy et al, 2017; Dlouhá et al, 2020)
Summary
Cardiovascular diseases and myocardial infarction (CVD, MI) are the major causes of death in industrial countries. Previous publications on this topic are sparse and typically characterised by low numbers of examined subjects and non-representative selections, they report that prevalence of CVD risk factors in Roma/Gypsy communities is higher than in majority populations (Dobranici et al, 2012).
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