Abstract
BackgroundIn recent years, some reports have suggested that papillary thyroid cancers are more frequently associated with lymphocytic thyroiditis or Hashimoto's thyroiditis. This study investigated a potential increase in the prevalence of chronic lymphocytic thyroiditis among papillary thyroid cancer patients.Materials and MethodsWe used national epidemiological survey data on thyroid cancer patients diagnosed in 1999, 2005, and 2008. A retrospective medical record survey was conducted by representative sampling of a national cancer incidence database. The analysis included 5,378 papillary thyroid cancer patients aged 20–79 years. We calculated the age-standardized prevalence and age-adjusted prevalence ratios using a binomial regression model with a log link for the prevalence of chronic lymphocytic thyroiditis among papillary thyroid cancer patients by sex for each year.ResultsThe prevalence of chronic lymphocytic thyroiditis among papillary thyroid cancer patients was 4.0% and 12.8% for men and women in 1999, 6.5% and 24.6% in 2005, and 10.7% and 27.6% in 2008, respectively. Between 1999 and 2008, the age-standardized prevalence of chronic lymphocytic thyroiditis increased 4.1-fold in male patients and 2.0-fold in female patients with papillary thyroid cancer. The prevalence of other thyroid diseases, however, did not increase in either gender.ConclusionsAmong Korean papillary thyroid cancer patients, the prevalence of chronic lymphocytic thyroiditis increased between 1999 and 2008, whereas the prevalence of other thyroid disorders did not change.
Highlights
The incidence of thyroid cancer has increased rapidly in most developed countries [1]
The proportion of extrathyroidal invasion of Papillary thyroid cancer (PTC) patients has significantly increased from 44.9% in 1999 to 51.2% in 2008 (p,0.001)
Proportion of stage III papillary thyroid cancer has increased from 13.4% in 1999 to 25.5% in 2008
Summary
The incidence of thyroid cancer has increased rapidly in most developed countries [1]. In Korea, which has the highest incidence of thyroid cancer in the world [2], the incidence increased rapidly between 1999 and 2010 from 2.1 to 18.3 per 100,000 in men and from 10.4 to 87.4 per 100,000 in women [3]. There have been several recent reports of increasing trends in thyroid disorders. In Korea, the prevalence of thyroid disorders increased from 1.0% in 1998 to 3.9% in 2010 among people $30 years of age [9]. Some reports have suggested that papillary thyroid cancers are more frequently associated with lymphocytic thyroiditis or Hashimoto’s thyroiditis. This study investigated a potential increase in the prevalence of chronic lymphocytic thyroiditis among papillary thyroid cancer patients
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