Abstract

haematological disorders, including plasma cell leukaemia and angioimmunoblastic lymphadenopathy. There was, however, no additional clinical or laboratory evidence for these diagnoses. The dramatic rise in the numbers of these cells was short lived with complete disappearance in three days. Although a renal biopsy was not performed, the renal failure was considered to be due to an acute hypersensitivity induced interstitial nephritis. Hydrocortisone, which was not given prophylactically to this patient, might have modified the immune and clinical response. Management after thrombolytic treatment has been controversial and it is not clear whether coronary angioplasty is beneficial in preventing reocclusion of the reperfused artery. If threatened reocclusion occurs either within five days or after three months following initially successful thrombolysis our policy has been to reattempt reperfusion with streptokinase. In this patient reocclusion was prevented by readministration of streptokinase, but his severe symptoms of angina continued and coronary surgery was required. If thrombolytic treatment is to be repeated at a time when an allergic reaction is likely, non-antigenic agents such as recombinant tissue plasminogen activator should be used.

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