Abstract
Disturbances in phospholipid metabolism have been suggested in schizophrenia (Rotrosen and Wolkin 1987; Brody et al 1987). There is increasing evidence from numerous studies on blood cells, mostly erythrocytes and platelets, that membrane phospholipid distribution is changed in schizophrenic patients, however, results are not consistent. Some studie.s indicate an increase in phosphatidylserine (PS) but decreases in phosphatidylcholine (PC)~and phosphatidylethanolamine (PE) (Steveni# 1972); other studies reported opposite results or no changes at all (Rotrosen and Wolkin 1987). It remains to be clarified whether these discrepancies are due to the investigation of different tissues or to the use of different laboratory procedures. We ~cantly fcmnd a marked difference in the activity, of the phospholipid metabolizing enzyme phospholipase A2 (PLA2), with significantly higher levels in plasma, serum, and platelets from schizophrenics than in healthy controls or nonschizophrenic psychiatric patiem~ (~Jai,.,:
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