Abstract
Overproduction of cysLTs is a hallmark of AERD, but the mechanisms for their production are incompletely defined. Because leukocytes can provide the precursor leukotriene (LT)A4 to adherent platelets for transcellular conversion to the parent cysLT, LTC4, we hypothesized that platelet-dependent leukotriene metabolism contributes to cysLT production in AERD.
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