Abstract
Background and purposeMetabolome analyses have shown that plasma amino acid profiles reflect various pathological conditions, such as cancer and diabetes mellitus. It remains unclear, however, whether plasma amino acid profiles change in patients with sarcopenia. This study therefore aimed to investigate whether sarcopenia-specific changes occur in plasma amino acid profiles.MethodsA total of 153 community-dwelling and seven institutionalized elderly individuals (56 men, 104 women; mean age, 77.7±7.0 years) were recruited for this cross-sectional analysis. We performed a comprehensive geriatric assessment, which included an evaluation of hand grip strength, gait speed, muscle mass and blood chemistry, including the concentration of 18 amino acids.ResultsTwenty-eight of the 160 participants met the criteria for sarcopenia established by the Asian Working Group on Sarcopenia in Older People. Univariate analysis revealed associations between the presence of sarcopenia and a higher plasma concentration of proline and glutamine, lower concentrations of histidine and tryptophan. Multivariable analysis revealed that a higher concentration of proline was the only variable independently associated with sarcopenia.ConclusionsThe plasma concentration of proline may be useful for understanding the underlying pathophysiology of sarcopenia.
Highlights
Sarcopenia is the age-associated loss of skeletal muscle mass, strength, and physical performance [1,2]
This study aimed to investigate whether sarcopenia-specific changes occur in plasma amino acid profiles
Twenty-eight of the 160 participants met the criteria for sarcopenia established by the Asian Working Group on Sarcopenia in Older People
Summary
Sarcopenia is the age-associated loss of skeletal muscle mass, strength, and physical performance [1,2]. It affects the mortality, cognitive function, and quality of life of elderly people [3]. Metabolome analyses have shown that plasma amino acid profiles reflect various pathological conditions, such as cancer and diabetes mellitus. It remains unclear, whether plasma amino acid profiles change in patients with sarcopenia. This study aimed to investigate whether sarcopenia-specific changes occur in plasma amino acid profiles
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