Abstract
IntroductionHeparin-binding protein (HBP) is an antimicrobial protein stored in neutrophil granules and plays a role in endothelial permeability regulation. The aim was to assess the diagnostic and prognostic value of measuring HBP in patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS).MethodsPlasma HBP was collected from 78 patients with ALI/ARDS, 28 patients with cardiogenic pulmonary edema (CPE) and 20 healthy volunteers at enrollment. Levels of HBP were measured by ELISA.ResultsPatients with ALI/ARDS had significantly higher median levels of HBP compared with patients with CPE (17.15 (11.95 to 24.07) ng/ml vs. 9.50 (7.98 to 12.18) ng/ml, P <0.001) at enrollment. There was no significant difference between CPE patients and healthy subjects in terms of HBP value (P = 0.372). The HBP levels of nonsurvivors was significantly higher than that of survivors (23.90 (14.81 to 32.45) ng/ml vs. 16.01 (10.97 to 21.06) ng/ml, P = 0.012) and multivariate logistic regression showed HBP (odds ratio =1.52, P = 0.034) was the independent predictor for 30-day mortality in patients with ALI/ARDS.ConclusionsPlasma HBP levels of ALI/ARDS patients were significantly higher than that of CPE patients. HBP was a strong prognostic marker for short-term mortality in ALI/ARDS.
Highlights
Heparin-binding protein (HBP) is an antimicrobial protein stored in neutrophil granules and plays a role in endothelial permeability regulation
Heparin-binding protein values Patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) had significantly higher median levels of HBP compared with patients with cardiogenic pulmonary edema (CPE) (17.15 (11.95 to 24.07) ng/ml vs. 9.50 (7.98 to 12.18) ng/ml, P
In patients with ALI/ARDS, higher baseline plasma HBP levels were strongly associated with fewer ventilator-free days (VFD) (P = 0.031) in 49 patients who received mechanical ventilation in analysis controlling for Acute Physiology and Chronic Health Evaluation (APACHE) II score, Lung Injury Score (LIS) score, PO2/ FiO2 and creatinine value
Summary
Patient characteristics A total of 126 people, 78 patients with ALI/ARDS, 28 patients with CPE and 20 healthy volunteers, were enrolled in the study. Heparin-binding protein values Patients with ALI/ARDS had significantly higher median levels of HBP compared with patients with CPE The difference of HBP levels between patients with severe sepsis and septic shock was not significant (27.12 (16.03 to 36.01) ng/ml vs 18.14 (11.79 to 22.95) ng/ml, P = 0.090) (Figure 2b). Univariate logistic regression analysis showed that age, APACHE II score, LIS, PO2/FiO2 and plasma HBP levels at enrollment were the common predictors of 30-day mortality in patients with ALI/ARDS. In patients with ALI/ARDS, higher baseline plasma HBP levels were strongly associated with fewer VFD (P = 0.031) in 49 patients who received mechanical ventilation in analysis controlling for APACHE II score, LIS score, PO2/ FiO2 and creatinine value. The HBP value, was not associated with nonpulmonary organ failure-free days in 52 patients who had at least one nonpulmonary organ failure in ALI/ARDS patients (Table 4)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
