Abstract
Plasma apolipoprotein A-IV (apoA-IV) levels are found elevated in hypertriglyceridemic patients. However, the relationship between plasma apoA-IV level and postprandial lipemia is not well known and remains to be elucidated. Thus, our objective was to study the relationship between plasma apoA-IV and postprandial TG after an oral fat load test (OFLT). Plasma apoA-IV was measured at fast and during an OFLT in 16 normotriglyceridemic, normoglucose-tolerant android obese subjects (BMI = 34.6 +/- 2.9 kg/m(2)) and 30 normal weight controls (BMI = 22.2 +/- 2.3 kg/m(2)). In spite of not statistically different fasting plasma TG levels in controls and obese patients, the former group showed an altered TG response after OFLT, featuring increased nonchylomicron TG area under the curve (AUC) compared with controls (516 +/- 138 vs. 426 +/- 119 mmol/l x min, P < 0.05). As compared to controls, obese patients showed increased apoA-IV levels both at fast (138.5 +/- 22.4 vs. 124.0 +/- 22.8 mg/l, P < 0.05) and during the OFLT (apoA-IV AUC: 79,833 +/- 14,281 vs. 68,176 +/- 17,463 mg/l x min, P < 0.05). Among the whole population studied, as among the control and obese subgroups, fasting plasma apoA-IV correlated significantly with AUC of plasma TG (r = 0.60, P < 0.001), AUC of chymomicron TG (r = 0.45, P < 0.01), and AUC of nonchylomicron TG (r = 0.62, P < 0.001). In the multivariate analysis, fasting apoA-IV level constituted an independent and highly significant determinant of AUC of plasma TG, AUC of chymomicron TG, AUC of nonchylomicron TG, and incremental AUC of plasma TG. In conclusion, we show a strong link between fasting apoA-IV and postprandial TG metabolism. Plasma fasting apoA-IV is shown to be a good marker of TG response after an OFLT, providing additional information on post-load TG response in conjunction with other known factors such as fasting TGs.
Highlights
IntroductionPlasma apolipoprotein A-IV (apoA-IV) levels are found elevated in hypertriglyceridemic patients
Plasma apolipoprotein A-IV levels are found elevated in hypertriglyceridemic patients
Postprandial lipid metabolism has received considerable attention because it has been shown that postprandial TG-rich lipoproteins are involved in the Abbreviations: apoA-IV, apolipoprotein A-IV; ALT, alanine aminotransferase; AST, aspartate amino-transferase; AUC, area under the curve; AUCi, incremental AUC; BMI, body mass index; ␥GT, gammaglutamyl transferase; HOMA, homeostasis model assessment; lecithin: cholesterol acyl transferase (LCAT), lecithin:cholesterol acyl transferase; OFLT, oral fat load test
Summary
Plasma apolipoprotein A-IV (apoA-IV) levels are found elevated in hypertriglyceridemic patients. Postprandial lipid metabolism has received considerable attention because it has been shown that postprandial TG-rich lipoproteins are involved in the Abbreviations: apoA-IV, apolipoprotein A-IV; ALT, alanine aminotransferase; AST, aspartate amino-transferase; AUC, area under the curve; AUCi, incremental AUC; BMI, body mass index; ␥GT, gammaglutamyl transferase; HOMA, homeostasis model assessment; LCAT, lecithin:cholesterol acyl transferase; OFLT, oral fat load test. Very little is known about the relationship between plasma apoA-IV level and postprandial lipemia, and so far, only few studies performed in a limited number of normal subjects have been reported [3, 32, 33]. To gain further insight into the relationship between apo-IV and postprandial lipid metabolism, we aimed to study the possible link between plasma apoA-IV and postprandial TG after an OFLT in normolipidemic obese subjects with altered post-fat load TG responses and in normal weight healthy controls
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