Abstract
There is increasing evidence that amphotericin B and other drugs of the polyene type cause damaging effects to different types of cells, including yeast [1], mycoplasmal [2, 3], and amphibian [4] and reptilian tissues [5]. Although the effects of these drugs differ in some details in different organisms, a common feature is loss of intracellular constituents; this has been ascribed either to a direct effect on transport [6, 7] or to a more general, undefined effect on the permeability of cell membranes [1]. There is relatively little information on these effects of the polyene drugs on mammalian cells.
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