Abstract
Primary mucosal melanoma (MM) is a rare, and aggressive, neoplasm with a poor prognosis. To date, few prognostic markers of MM have been well-defined. The aim of this study is to clarify the prognostic value of p53 and p16 proteins in predicting the clinical outcome of Chinese patients with MM.A total of 59 MM samples were contained from biopsy specimens, and, expressions of p53 and p16 proteins were assessed by immunohistochemistry. Cox regression analysis was performed to investigate the association of these proteins with the overall survival of MM patients. Increased p16 expression was significantly associated with reduced survival at three years (P=0.039). Increased p53 expression correlates with reduced one-year (P=0.025), and, two-year survival (P=0.037).Increased p53 and p16 protein expression may be helpful prognostic indicators for the management of these patients.
Highlights
Mucosal Melanoma (MM) is a rare subtype of malignant melanoma representing approximately 1.3% of all melanomas [1,2,3,4]
A total of 59 MM samples were contained from biopsy specimens, and, expressions of p53 and p16 proteins were assessed by immunohistochemistry
Stratified by anatomic sites, five-year overall survival rate for primary MM varies with 30% for the head and neck, 10% for the female lower genital tract and 20% for the anorectum [5]
Summary
Mucosal Melanoma (MM) is a rare subtype of malignant melanoma representing approximately 1.3% of all melanomas [1,2,3,4]. Primary MM may arise from the head and neck (55%), female genital tract (18%), anorectal (24%), or urinary tract (3%), respectively [5]. The prevalence of this disease is relatively low, it has become increasingly clear that primary MM leads to worse outcome than other subtypes of melanoma. Stratified by anatomic sites, five-year overall survival rate for primary MM varies with 30% for the head and neck, 10% for the female lower genital tract and 20% for the anorectum [5]. This suggests that primary MM is a biologically-heterogeneous disease with wide variations in prognosis
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