Abstract
There is ample evidence that allergic disorders such as asthma, rhinitis and atopic dermatitis are mediated by oxidative stress. Excessive exposure to reactive oxygen and nitrogen species is the hallmark of oxidative stress and leads to damage of proteins, lipids and DNA. Oxidative stress occurs not only as a result of inflammation but also from environmental exposure to air pollution and cigarette smoke.
Highlights
There is ample evidence that allergic disorders such as asthma, rhinitis and atopic dermatitis are mediated by oxidative stress
As we have previously shown that asthma is associated with increased oxidant burden and decreased anti-oxidant defence both in the systemic circulation and locally
Allergic disorders such as rhinitis, asthma as well as atopic dermatitis are mediated by oxidative stress
Summary
There is ample evidence that allergic disorders such as asthma, rhinitis and atopic dermatitis are mediated by oxidative stress. Disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids and DNA Allergic disorders such as rhinitis, asthma as well as atopic dermatitis are mediated by oxidative stress. In allergic rhinitis the immune system uses the lethal effects of oxidants by making production of oxidizing species a central part of its mechanism of killing pathogens; with activated phagocytes producing Reactive Oxygen Species and reactive nitrogen species. These include superoxide, nitric oxide and their particular reactive product, peroxynitrite. The effects of oxidative stress depend upon the size of these changes, with a cell being able to overcome small perturbations and regain its original
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