Abstract
Zinc is an essential micronutrient largely recognized by its structural role in enzymes and transcription factors and more recently in signal transduction. Dietary zinc promotes beneficial effects and its deficiency is associated with diverse diseases including cardiovascular and neurodegenerative diseases by incompletely understood mechanisms. Using ApoE KO mice fed zinc deficient (3 ppm zinc), zinc adequate (80 ppm zinc) and zinc supplemented (300 ppm zinc) diets, we found that zinc deficiency accelerates senescence, a hallmark of mammalian aging, which is associated with the onset and progression of cardiovascular disease. In contrast, zinc supplementation ameliorates the increase in senescence induced by Angiotensin II (Ang II), a strong stimulator of vascular aging and disease. Ang II as well as zinc deficiency decreased the expression of the zinc transporters ZnT3, which work to reduce cytosolic zinc levels. Using aortic vascular smooth muscle cells (VSMCs) in vitro, we found that ZnT3 downregulatio...
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