Increased oxidative damage in the plasma of adult type 2 diabetics with poor glycemic control (693.7)

Abstract

Increased oxidative damage in the plasma of adult Type 2 diabetics with poor glycemic control Increasing evidence associates oxidative stress with the pathogenesis of Type 2 Diabetes (T2DM). Nonetheless, the available data related to oxidative stress and its relationships with glycemic status among T2DM patients are scarce and contradictory.Our goal was to investigate the relationships of metabolic control of T2DM with oxidative damage and antioxidant status.T2DM Emirati adults (n=187), participating in the Skills for Change randomized intervention trial and recruited from seven different ambulatory health care centers in Al Ain, United Arab Emirates, were considered. 24 h‐recall was collected. Anthropometry and HbA1c were assessed. Aantioxidant status markers were measured: Vitamin C, ABTS, Ferric Reducing Ability of Plasma (FRAP) and Glutathione (GSH). After stratification on HbA1c and age, oxidative damage (Malonaldehyde (MDA), protein carbonyls) were assessed in a sub‐sample (n=47).Means ± s.d. or percentages were calculated as appropriate. General linear model was used with adjustment for age, body mass index, food groups’ consumption (fruits, vegetables meat/beans, dairy), fat and total daily energy intakes.In the whole sample, mean age was 53.46±9.36 years, mean HbA1c was 7.69±1.54 %. A majority (86.50%) of patients was taking oral medication. Mean values for vitamin C, ABTS, FRAP and GSH were 0.09±0.07 g/L, 0.10±0.04 g /L, 1.00±0.46 g/L and 0.13±0.03 g/L, respectively. In the sub‐sample, MDA and protein carbonyls were 12.67±3.44 µmol/L and 0.29 nmol/L, respectively. None of the markers of antioxidant status were significantly related to HbA1c. MDA and protein carbonyls were strongly positively associated with HbA1c (p=0.02, 0.01, respectively).In this work, poor glycemic control is strongly positively associated with oxidative damage in adults with T2DM, suggesting that oxidative stress is closely intertwined with this disease.Grant Funding Source: Supported by Sheikh Hamdan Award