Abstract
Acute noradrenergic stimulation has previously been shown to stimulate brain (Na +, K +)- adenosine triphosphatase activity. Effects of repeated stimulation with piperoxane were examined in the present study. Daily piperoxane increased ouabain binding, measured 24 h after the last dose, after 4 days or 3 weeks treatment; K +-p-nitrophenylphosphatase was increased after 3 weeks. Prazosin, which, like piperoxane, activates presynaptic noraadrenergic neurons but, unlike piperoxane, blocks postsynaptic receptors, did not increase K +-p-nitrophenylphosphatase , and decreased ouabain binding after 3 weeks.
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