Abstract
In the rabbit, ovulation and conception occur during an 8-10 hour period immediately following mating ("reflex ovulation"). We report here that live Newcastle disease virus (NDV; an avian paramyxovirus) injected into rabbits immediately following mating resulted in a high frequency of embryo death at a wide range of developmental stages. When measured at midterm, a greater than threefold increase in embryo mortality was observed (24.7% vs. 6.8%). Aneuploidy of a small acrocentric chromosome was observed in three of 60 live midterm embryos recovered from NDV-injected does. No aneuploidy was observed in 52 live midterm embryos from control, saline-injected does. These observations suggest that the NDV-exposed rabbit can provide a useful model for the study of the teratological effects of virus exposure occurring at or about the time of meiosis, ovulation, and conception.
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