Abstract
BackgroundOsteoporosis and migraine are both important public health problems and may have overlapping pathophysiological mechanisms. The aim of this study was to use a Taiwanese population-based dataset to assess migraine risk in osteoporosis patients.MethodsThe Taiwan National Health Insurance Research Database was used to analyse data for 40,672 patients aged ≥20 years who had been diagnosed with osteoporosis during 1996–2010. An additional 40,672 age-matched patients without osteoporosis were randomly selected as the non-osteoporosis group. The relationship between osteoporosis and migraine risk was estimated using Cox proportional hazard regression models.ResultsDuring the follow-up period, 1110 patients with osteoporosis and 750 patients without osteoporosis developed migraine. After controlling for covariates, the overall incidence of migraine was 1.37-fold higher in the osteoporosis group than in the non-osteoporosis group (3.72 vs. 1.24 per 1000 person-years, respectively). Migraine risk factors included high Charlson Comorbidity Index score, female gender, hypertension, depression, asthma, allergic rhinitis, obesity, and tobacco use disorder.ConclusionsOur results indicate that patients with a history of osteoporosis had a higher risk of migraine.
Highlights
Osteoporosis and migraine are both important public health problems and may have overlapping pathophysiological mechanisms
Caution is needed when extrapolating the results to other ethnic groups; further studies are needed to determine whether these findings can be generalized to other ethnicities. This retrospective cohort study may have been biased by unrecognized or unadjusted confounding variables, despite the use of statistical methods for reducing their confounding effects. In summary, this nationwide population-based cohort study revealed that adult patients with osteoporosis had a significantly higher risk of developing subsequent migraine compared to controls without osteoporosis
Clinicians should be aware that osteoporosis is a potential risk factor for migraine
Summary
Osteoporosis and migraine are both important public health problems and may have overlapping pathophysiological mechanisms. The aim of this study was to use a Taiwanese population-based dataset to assess migraine risk in osteoporosis patients. Both osteoporosis and migraine are common conditions that can affect quality of life and can impose large social and economic burdens (Kuo et al 2015; Manandhar et al 2015a, b; Mbewe et al 2015; Rao et al 2015; Steiner et al 2015; Lampl et al 2016). The National Institutes of Health Consensus Development Conference Statement defines osteoporosis as a skeletal disorder characterized by diminished bone strength resulting in increased fracture risk. We investigated the impact of osteoporosis on migraine risk in a nationwide cohort in Taiwan
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