Abstract
Methods: The fecal microbiota of a subset of 17 patients who participated in the PUNCH CD study assessing RBX2660 (microbiota suspension) for recurrent CDI were characterized at 7 and 60 days post treatment using 16S rRNA gene sequencing in a post-hoc analysis. The patients (median 69.2 years; 65% female; 94% white) included 8 successes with 1 dose of RBX2660; 6 with 2 doses and 3 failures with 2 doses. All patients received a standardized 7-day course of vancomycin prior to dose 1 of RBX2660. A second dose was permitted within 10 days of recurrence; administered without antibiotic pretreatment. DNA sequencing was performed on an Illumina MiSeq platform. The 16S sequences were clustered into operational taxonomic units and used to determine within-sample diversity and taxonomic composition at each time point. Weighted Unifrac analysis was used to determine differences between sample diversity.
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