Abstract
Findings In athletes with AHR, the PC20 (expressed as the mean of double concentrations (DC) ± standard error) was 0.7 ± 1.2 DC lower when MIT followed EVH (p = 0.015), while there was no significant difference in athletes without AHR (-0.4 ± 0.8 DC) nor in control subjects (0.4 ± 0.7 DC). When grouping subjects based on the EVH response, those with a positive response (FEV1 fall ≥ 10%) had a mean PC20 0.8 ± 1.1 DC lower when MIT followed EVH (p = 0.0008) while in those with no response to EVH (FEV1 fall <10%), airway responsiveness was not influenced by this test (0.05 ± 0.76 DC).
Highlights
Eucapnic voluntary hyperpnea (EVH) and methacholine inhalation test (MIT) are commonly used to evaluate airway responsiveness in athletes
Objective/purpose To evaluate the effects of EVH on the methacholine response in athletes with and without airway hyperresponsiveness (AHR) compared to control subjects
In athletes with AHR, the PC20 (expressed as the mean of double concentrations (DC) ± standard error) was 0.7 ± 1.2 DC lower when MIT followed EVH (p = 0.015), while there was no significant difference in athletes without AHR (-0.4 ± 0.8 DC) nor in control subjects (0.4 ± 0.7 DC)
Summary
Eucapnic voluntary hyperpnea (EVH) and methacholine inhalation test (MIT) are commonly used to evaluate airway responsiveness in athletes. Increased methacholine sensitivity after eucapnic voluntary hyperpnea Evelyne Blouin*, Valérie Bougault, Julie Turmel, Louis-Philippe Boulet From AllerGen NCE Inc.’s Fifth Annual Research Conference: Innovation from Cell to Society Québec City, QC, Canada.
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