Abstract
1. 1. The effects of increased mastication on submandibular gland development were studied in immature Sprague-Dawley rats, 32 days old. 2. 2. Increased mastication had no effect on body wt, submandibular gland weight or acinar cell size. 3. 3. DNA, RNA, protein, peroxidase and an androgen-dependent alkaline protease were unaffected by increased mastication. 4. 4. Alkaline protease, a product of the granular convoluted tubules, was greater in male than in female rats. 5. 5. Conversely, peroxidase activity which is of acinar cell origin was greater in the submandibular glands of female animals.
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