Abstract
The activity of cytosolic malic enzyme was significantly higher (61%) in the liver of rats fed a selenium-deficient diet compared with the controls. Activities of two other NADPH-generating enzymes, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase, were also increased but to a lesser extent (13%). Glutathione reductase, an NADPH-consuming enzyme involved in the metabolism of glutathione, was higher (26%) in the liver of selenium deficient rats, possibly as a result of an increase in glutathione synthesis and enzymic processes that maintain glutathione in the reduced state. It is concluded that an increased demand for NADPH in selenium deficiency, possibly resulting from increased glutathione metabolism, may induce NADPH-generating enzymes, especially malic enzyme. ( J. Nutr. Biochem. 5:314–316, 1994.)
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