Abstract
Chronic progressive lung disease is the leading cause of death in patients with cystic fibrosis (CF). The lung pathology is characterized by severe neutrophil-dominated inflammation with progressive fibrosis and loss of pulmonary function. Leukotriene B4 (LTB4) plays a key role in the pathophysiology of CF by recruiting activated neutrophils at sites of injury. Nitric oxide (NO), a highly reactive free radical molecule, may also function as a mediator of inflammation in lung diseases. The purpose of this study was to ascertain whether NO is produced in patients with CF and to determine a possible relationship between NO and LTB4 levels in CF. Seven patients with CF and 10 healthy volunteers were used in the present study. Assessment of CF was based on positive sputum cultures for Pseudomonas aeruginosa. Levels of NO and LTB4 were measured in the sera of patients with CF and normal controls using the Griess reaction for NO and radioimmunoassay for LTB4 detection. Both levels of NO and LTB4 in the sera of t...
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