Abstract
BackgroundObstructive sleep apnea-hypopnea syndrome (OSA) may cause liver fibrosis, and liver fibrosis serum biomarkers plays an important role on the diagnosis of liver fibrosis. In addition, this study aimed to observe the changes of 4 serum markers and Chitinase 3-like protein 1 (CHII3L1) levels in OSA patients with different disease severity and explore their interactions. And then, we examined whether intermittent hypoxia (IH) exposure can activate hepatic stellate cell.Methods74 OSA patients in Second Xiangya hospital from January 2021 to October 2021 was selected and categorized into mild, moderate, and severe groups according to AHI. In addition, 20 subjects were selected as the control group. Serum levels of liver fibrosis markers were determined by electrochemiluminescence immunoassay. Hepatic stellate cells were exposed to intermittent IH or normoxia (RA). Results were analyzed using the SPSS software.ResultsThere was a significant increase in serum hyaluronic acid (HA), collagen type IV (CIV) and CHI3L1 levels in OSA patients compared with control group. Specifically, serum liver fibrosis markers HA, CIV and CHI3L1 levels were positively correlated with apnea-hypopnea index (AHI), but negatively correlated with the lowest saturation oxygen (LSaO2) respectively. The LX-2 cells (human hepatic stellate cell line) exposed to IH showed significant increases in fibrotic protein expression.ConclusionOSA might either directly or indirectly trigger or exacerbate liver fibrosis, possibly via IH-related pathways.
Highlights
Obstructive sleep apnea-hypopnea syndrome (OSA) is a common disorder that affects all age groups, especially middleaged and elderly people [1]
There was a significant increase in serum hyaluronic acid (HA), collagen type IV (CIV) and Chitinase 3-like 1 (CHI3L1) levels in OSA patients compared with control group
Serum liver fibrosis markers Hyaluronic acid (HA), CIV and CHI3L1 levels were positively correlated with apnea-hypopnea index (AHI), but negatively correlated with the lowest saturation oxygen (LSaO2) respectively
Summary
Obstructive sleep apnea-hypopnea syndrome (OSA) is a common disorder that affects all age groups, especially middleaged and elderly people [1]. It is characterized by intermittent episodes of upper airway obstruction during sleep, resulting in increased respiratory effort, recurrent decreased arterial oxygen saturation and sleep disruption [2]. Biopsy has long been touted as the gold standard for the assessment of liver fibrosis It has been limited by its invasiveness, cost, associated complications, sampling variability, and potential risks of clinical application [7]. We examined whether intermittent hypoxia (IH) exposure can activate hepatic stellate cell
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