Abstract
The biology of chronic migraine (CM) as a true entity or as a consequence of analgesic overuse is controversial. There are no available biological markers for CM, while CGRP, a marker of trigemino-vascular activation, has been shown to be increased during acute migraine attacks in episodic migraine [1].
Highlights
The biology of chronic migraine (CM) as a true entity or as a consequence of analgesic overuse is controversial
CGRP levels were determined in blood samples obtained from right cubital vein between 9-12 am with an ELISA kit from USCN following manufacturer’s instructions
CGRP levels were increased in women with CM (77.94 ng/ml, range 27.69-157.72) as compared to controls (40.39 ng/ml, range 20.08-70.75) (+93%; p
Summary
The biology of chronic migraine (CM) as a true entity or as a consequence of analgesic overuse is controversial. Increased levels of CGRP in peripheral blood in women with chronic migraine: A reliable biological marker E Cernuda-Morollon1, D Larrosa2, G Moris2, C Ramon2, J Pascual2*
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