Increased length-dependent activation of human engineered heart tissue after chronic treatment with alpha-1A-adrenergic agonist

Cassady Rupert,Elizabeth Cortez-Toledo,Javier E Lopez,Naomi C Chesler,Paul C Simpson,Stuart G Campbell,Anthony J Baker

doi:10.1016/j.bpj.2021.11.785

Increased length-dependent activation of human engineered heart tissue after chronic treatment with alpha-1A-adrenergic agonist

Cassady Rupert, Elizabeth Cortez-Toledo + Show 5 more

Open Access

https://doi.org/10.1016/j.bpj.2021.11.785

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Journal: Biophysical journal	Publication Date: Feb 1, 2022
License type: publisher-specific-oa

Affiliation: University of California, Davis, University of California, Irvine, University of California, San Francisco, Yale University

#Human Engineered Heart Tissue #Animal Models Of Heart Failure + Show 8 more

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Abstract

Recent preclinical studies show that chronic stimulation of the cardiac α1A-adrenergic receptor (α1A-AR) has beneficial effects in multiple animal models of heart failure. However, direct evidence in human is lacking. Human engineered heart tissues (EHT) provide a means of quantifying effects of chronic α1A-AR stimulation on human cardiomyocyte physiology.

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