Abstract
Purpose of investigation: In normal conditions, circulating kisspeptin levels dramatically increase during the first trimester of pregnancy and fall approximately five days post-delivery to concentrations comparable to those detected prior to pregnancy. Dysregulation of trophoblast invasion results in a wide spectrum of abnormal pregnancies such as preeclampsia, premature delivery, and choriocarcinoma. The aim of the present study was to investigate the expression profile of KiSS-1 in abnormally adherent placenta specimens (placenta accreta and placenta praevia). Materials and Methods: Ten term trophoblast preparations (five normal adhesions, four placenta accretae and one placenta praevia) were obtained for RNA extraction and immunohistochemistry in order to determine KiSS-1 mRNA and protein levels. Results: KiSS-1 mRNA expression was found to be increased in conditions of pathological placental adhesion compared to normal tissues. Conclusion: KiSS-1 is implicated in the regulation of placental invasion as part of a compensatory inhibition to abnormal placental adhesion.
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