Abstract
1. The time for perforation to occur in dogs’ intestines was studied by exposing the intestinal mucosa to a solution of 0.1 per cent pepsin in N/10 HCl under 90 cm. hydrostatic pressure and using intra-abdominal counter pressures of either 20 cm. or 45 cm. of saline. 2. The time for perforation to appear was lengthened by raising the intra-abdominal pressure, varying directly with the pressure. When the intra-abdominal pressure was atmospheric the time for perforation was 82 minutes; when the pressure in the abdomen was 20 cm. saline the time was increased to 116 minutes and at 45 cm. pressure, to 185 minutes.
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