Abstract
Tetracycline-resistant pneumococci have lately become more common in the Liverpool area. In 1968, 23% of pneumococci isolated from patients at Liverpool Royal Infirmary were tetracycline-resistant. At least half of these infections were acquired outside hospital. From patients at home and from children newly admitted to hospital, the proportion of tetracycline-resistant pneumococci isolated at a Public Health Laboratory increased from 9% in 1967 to 14% in 1968. Infections caused by resistant pneumococci did not respond to treatment with tetracyclines and many developed during or after administration of these antibiotics. It is important that infections which may be pneumococcal and fail to respond to tetracycline treatment should be investigated bacteriologically to establish the nature and sensitivity of the infecting organism. When this is not possible, and in severe infections, treatment other than tetracycline should be used. Among pneumococci, resistance to the penicillins has not been observed and resistance to erythromycin and lincomycin is rare.
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