Abstract
BackgroundIt is unclear whether liver transplantation is associated with an increased incidence of post-transplant head and neck cancer. This comprehensive meta-analysis evaluated the association between liver transplantation and the risk of head and neck cancer using data from all available studies.MethodsPubMed and Web of Science were systematically searched to identify all relevant publications up to March 2014. Standardized incidence ratio (SIR) and 95% confidence intervals (CIs) for risk of head and neck cancer in liver transplant recipients were calculated. Tests for heterogeneity, sensitivity, and publishing bias were also performed.ResultOf the 964 identified articles, 10 were deemed eligible. These studies included data on 56,507 patients with a total follow-up of 129,448.9 patient-years. SIR for head and neck cancer was 3.836-fold higher (95% CI 2.754–4.918, P = 0.000) in liver transplant recipients than in the general population. No heterogeneity or publication bias was observed. Sensitivity analysis indicated that omission of any of the studies resulted in an SIR for head and neck cancer between 3.488 (95% CI: 2.379–4.598) and 4.306 (95% CI: 3.020–5.592).ConclusionsLiver transplant recipients are at higher risk of developing head and neck cancer than the general population.
Highlights
It is unclear whether liver transplantation is associated with an increased incidence of post-transplant head and neck cancer
Liver transplant recipients are at higher risk of developing head and neck cancer than the general population
Publication search A systematic, comprehensive literature search was carried out using the PubMed and Web of Science databases, to identify all articles investigating the risk of head and neck cancer in liver transplant recipients
Summary
It is unclear whether liver transplantation is associated with an increased incidence of post-transplant head and neck cancer. This comprehensive meta-analysis evaluated the association between liver transplantation and the risk of head and neck cancer using data from all available studies. Because of differences in study design, sample selection, sample size, and follow-up period, the association between liver transplantation and head and neck cancer remains unclear. This meta-analysis, which included all relevant studies on head and neck cancer and liver transplantation, was performed to clarify whether the total standardized incidence rate (SIR) of head and neck cancer is higher following liver transplantation than in the general population
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