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Abstract
The aim of this study was to investigate and analyze the incidence of early-onset colorectal cancer in Arizona, using the Arizona Cancer Registry. We performed a retrospective analysis of patients with colorectal cancer reported in the Arizona Cancer Registry from 1995-2010. Outcome measure: incidence of CRC in patients younger than 50 years. 39,623 cases of colorectal cancer were reported to the Arizona Cancer Registry during a period of 15 years. Overall, there was a 17% decrease in the incidence of CRC. However, there was a 23% increase in incidence among patients in the age group 10-50. During the same time period, 15% and 41% increase in the incidence of colon and rectal cancer was observed, respectively. The most significant increase (102%) in overall CRC incidence was seen in the age group 10-29. The highest increase (110%) in incidence of colon cancer was observed in the same age group, while the most significant increase in incidence rates (225%) of rectal cancer was seen in the age group 30-34. Although there is an overall decrease in incidence of colorectal cancer in Arizona, alarming increase in incidence of early-onset CRC was observed; mirroring the national trends.
Highlights
The aim of this study was to investigate and analyze the incidence of early-onset colorectal cancer in Arizona, using the Arizona Cancer Registry
Conclusion— there is an overall decrease in incidence of colorectal cancer in Arizona, alarming increase in incidence of early-onset Colorectal cancer (CRC) was observed; mirroring the national trends
Recent studies that used the Surveillance, Epidemiology, and End Results (SEER) database have shown that more than one-tenth of the newly diagnosed CRC cases (11% of colon cancers and 18% of rectal cancers) have a young onset and that the associated mortality rates for those with young-onset CRC have been increasing by approximately 2% annually since 2009 [6,7,8,9]
Summary
The aim of this study was to investigate and analyze the incidence of early-onset colorectal cancer in Arizona, using the Arizona Cancer Registry. The overall CRC incidence and mortality have been declining in both men and women since about 1990 [4], most likely due to progressive improvements in population screening, several recent studies have shown alarming increase in the incidence of CRC in patients younger than 50 [5, 6]. Recent studies that used the Surveillance, Epidemiology, and End Results (SEER) database have shown that more than one-tenth of the newly diagnosed CRC cases (11% of colon cancers and 18% of rectal cancers) have a young onset and that the associated mortality rates for those with young-onset CRC have been increasing by approximately 2% annually since 2009 [6,7,8,9]. The age-adjusted mortality rates have shown decreasing trends in older patients by 2% to 3% annually between 1992 and 2009 [2, 4]
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