Abstract
We assessed the association between metabolic health status and the incidence of bladder cancer using nationally representative data from the National Health Insurance System and National Health Checkups (NHC) databases in South Korea. Data for 11,781,768 men who participated in the NHC between 2009 and 2012 were analysed. The normal-weight and physically obese categories were defined as body mass indexes (BMI) < 25 and ≥25 kg/m2, respectively. Metabolically obese was defined as the presence of ≥3 components of metabolic syndrome. The participants were stratified into metabolically healthy, normal-weight (MHNW); metabolically obese, normal-weight (MONW); metabolically healthy, obese (MHO); metabolically obese, obese (MOO). Multivariate-adjusted Cox regression analysis was conducted to examine the association between metabolic health status and the incidence of bladder cancer. The study participants included 17,777 men newly registered with bladder cancer. Analysis according to metabolic health status classification revealed a higher multivariable-adjusted hazard ratio in the MOO, MONW group than in the MHO group (1.307 [95% CI: 1.258–1.358], 1.183 [95% CI: 1.137–1.231] and 1.066 [95% CI: 1.017–1.119], respectively; hazard ratios given relative to MHNW group) We found an association between metabolic health status and the incidence of bladder cancer, with an increasing risk according to the number of metabolic health status components.
Highlights
Obesity is associated with diabetes, cardiovascular disease, several types of cancers, and a decreased life expectancy[1]
Body size phenotypes were classified according to body mass index (BMI), which was calculated from measured height and weight, and the presence or absence of metabolic syndrome according to the results of the NHC17
12,471 subjects who were previously diagnosed with bladder cancer were excluded
Summary
Obesity is associated with diabetes, cardiovascular disease, several types of cancers, and a decreased life expectancy[1]. The existing studies on cancer epidemiology are mostly on the effects of obesity or metabolic syndrome on cancer incidence; this subject has not been sufficiently explored with regard to the metabolic health status. There have been studies on the relationship between obesity and bladder cancer[11,12] and between metabolic syndrome and bladder cancer[13,14], but no study has been conducted on the relationship between bladder cancer and metabolic health It is unknown whether bladder cancer risk is different for metabolically healthy obese and metabolically obese normal weight men. We aimed to assess the association between metabolic health status and the incidence of bladder cancer using nationally representative data of the Korean population
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
