INCREASED HOMOCYSTEINE PLASMA LEVELS IN BREAST CANCER PATIENTS OF A MEXICAN POPULATION

Abstract

Hyperhomocysteinemia has been associated with different pathologies, including cardiovascular diseases, hypertension, diabetes, and breast cancer (BC). To examine the differences in total homocysteine (tHcy) plasma levels, we compared healthy women to BC patients from a Mexican population. The tHcy plasma levels were measured using high-performance liquid chromatography with a fluorescence detector in 89female controls and 261BC patients. The observed plasma tHcy levels were significantly higher among the BC patients (11.1019 ± 5.9161µmol/l) compared to the controls (9.1046±1.3213µmol/l) (p=0.002), and these differences were evident when stratified by age (≥50years old), menopause status, overweight and obesity, miscarriages, node metastases, progression, subtype classification (luminal, Her2and triple negative) and nonresponse to chemotherapy. The tHcy plasma levels could be a good marker for the progression and chemosensitivity of BC in the analyzed sample from a Mexican population.