Abstract
19 Indian children with liver disease were studied. 5 in whom a clinical and histological diagnosis of Indian Childhood Cirrhosis was made had massive orcein-staining deposits in liver cells. The hepatic copper content in these 5 cases was strikingly high (1389 μg/g dry tissue, range 1045-2303) the normal range being 15-55 μg/g. Of the other 14 cases, only 2 had hepatic copper levels above normal (170 and 292 μg/g.) This high hepatic copper concentration may be caused by excessive copper ingestion or an abnormality of copper metabolism.
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