Increased Glycated Hemoglobin but Decreased Cholesterol after a Loss of Helicobacter pylori Infection: A Community-Based Longitudinal Metabolic Parameters Follow-Up Study.

Li-Wei Chen,Rong-Nan Chien,Chih-Lang Lin,Cheng-Hung Chien

doi:10.3390/jpm11100997

Li-Wei Chen, Rong-Nan Chien + Show 2 more

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https://doi.org/10.3390/jpm11100997

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Abstract

This study aimed to evaluate the impact of Helicobacter pylori (H. pylori) infection on metabolic parameters in a longitudinal follow-up manner. From August 2013 to August 2019, a community-based prospective study of H. pylori and metabolic syndrome (MetS) was performed in the northeastern region of Taiwan. A total of 1865 subjects were divided into four groups according to the serial results of urea breath test (UBT): new H. pylori infection (group 1, n = 41), null H. pylori infection (group 2, n = 897), loss of H. pylori infection (group 3, n = 369), and persistent H. pylori infection (group 4, n = 558). When comparing the subjects between groups 1 and 2, HBA1c was associated with a new H. pylori infection. Body mass index (BMI) was associated with a loss of H. pylori when comparing subjects between groups 3 and 4. Elevated HBA1c and high-density lipoprotein (HDL) levels but lower values of cholesterol and white blood cells (WBCs) were found during serial analyses within group 3. Conclusively, HBA1c was associated with a new H. pylori infection. BMI was associated with H. pylori loss. Increased HBA1c and HDL values but decreased values of cholesterol and WBC were associated with a loss of H. pylori infection.

Highlights

Helicobacter pylori (H. pylori) infection is the most common chronic bacterial infection in humans
HBA1c was associated with a new H. pylori infection
The patients were divided into four groups: new H. pylori infection group, null H. pylori infection group, loss of H. pylori infec4toiofn10group, and persistent H. pylori infection group (Figure 1)

Summary

Introduction

Helicobacter pylori (H. pylori) infection is the most common chronic bacterial infection in humans. Some immune related cells, such as mast cell, macrophage, and T-cell, are involved in H. pylori infected reaction. H. pylori infection is associated with increased expression of the macrophage migratory inhibitory factor (MIF) protein and MIF mRNA in gastric epithelial and inflammatory cells; along with other cytokines, MIF may play a significant role in gastric inflammation [6]. Elevated levels of inflammatory cytokines, such as interleukin 1, 8, 17, tumor necrosis factor α (TNF-α), and lowered levels of leptin are involved in these inflammatory reactions [3,7,8]. Our previous studies revealed subjects aged less than 50 y/o with H. pylori infection increased a risk of being obesity (BMI ≥ 30) (Odd ratio, OR = 1.836), IR (OR = 12.683), and MetS (OR = 3.717) compared to those without H. pylori infection [2,15]

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