Abstract
Wide interpatient variations were demonstrated in gentamicin elimination rate and dosage requirements for 249 gynecology patients with normal renal function. These variations combined with the need to obtain narrow ranges in serum levels necessitated measuring serum concentrations and individually calculating each patient's dose and dosing interval. Optimal peak and trough serum concentrations were reliably and rapidly achieved by means of this method. Required dosage regimens ranged from 1.9 to 14.0 mg/kg/day. Ototoxicity and nephrotoxicity did not occur in these patients. These results further emphasize the need to measure serum concentrations and make necessary dosage adjustments to ensure therapeutic levels. However, because of the wide interpatient variation, these increased dosages are not routinely suggested without previously measuring serum concentrations and calculating each patient's dosage regimen.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
