Increased functional segregation of brain network associated with symptomatology and sustained attention in chronic post-traumatic stress disorder

Abstract

BackgroundTraditional regional or voxel-based analyses only focus on specific brain regions or connectivity rather than the whole brain's functional organization. Using resting state functional magnetic resonance imaging (rs-fMRI), we aimed to explore the altered topological metrics, clinical symptoms and cognitive function in chronic post-traumatic stress disorder (PTSD) in order to identify the brain network mechanisms underlying these clinical and cognitive symptoms. MethodsForty patients with unmedicated chronic PTSD and forty-two matched trauma-exposed healthy controls (TEHCs) underwent rs-fMRI, and the topological organization of the whole-brain network was calculated using graph theory. The Rapid Visual Information Processing (RVP) task and Wechsler Memory Scale-IV (WMS-IV) were used to evaluate the subjects’ sustained attention and memory capacity. All clinical and cognitive measures and topological parameters of the PTSD patients and TEHCs were compared, and the relationships between altered network metrics and symptom severity were explored. ResultsCompared with the TEHCs, the patients showed increases in the normalized clustering coefficient, small-worldness, normalized local efficiency and efficiency-based small-worldness. The left middle occipital gyrus showed increases in nodal global efficiency and nodal degree that were negatively correlated with the severity of PTSD symptoms. The altered connections in PTSD only involved the default mode network (DMN) and the occipital network. LimitationsComorbid conditions were included, and current cross-sectional study cannot conclude on causality. ConclusionsPatients with chronic PTSD showed increased functional brain network segregation, mainly in the occipital cortex, which could be a protective or compensatory mechanism to alleviate clinical symptoms.