Increased Fibrinolytic Capacity after Intervention on Diet in Healthy Coronary High‐risk Men

Abstract

In a study of 42 healthy, middle‐aged men with high risk of coronary heart disease (CHD), especially on the basis of hyperlipoproteinaemia, a highly significant correlation was found between the euglobulin clot lysis time (ECLT) after venous stasis and serum triglyceride concentration (p < 0.01), whereas no such correlation was found between ECLT and serum cholesterol. In accordance with these findings, delayed clot lysis was mostly associated with types IIB and IV hyperlipoproteinaemia. Twenty‐two of the participants had been defined as excellent diet responders on the basis of diet recording and serum lipid lowering, whereas the other 20 were controls. Following dietary changes with normalization of hypertriglyceridaemia, significantly more good diet responders of the intervention group had increased fibrinolytic capacity as compared with the control group (p < 0.02). Thus it seems possible to normalize both the lipoprotein pattern and the fibrinolytic capacity to some extent through dietary advice, which again may contribute to less clinical events of CHD.