Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis.

Federico Biscetti,Vincenzo Arena,Antonio Bianchi,Raffaele Landolfi,Giovanni Bertoletti,Claudio Vincenzoni,Giuseppe Straface,Egidio Stigliano,Andrea Flex,Giovanni Pecorini,Carlo Filippo Porreca,Flavia Angelini,Francesco Snider

doi:10.1186/s12933-015-0301-5

Abstract

BackgroundThe object of this study was to investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis.MethodsIn this retrospective observational study, we analyzed FGF23 serum level in 361 type 2 diabetic patients with internal carotid artery stenosis undergoing carotid endarterectomy and in 598 diabetic controls without carotid atherosclerosis.ResultsWe found that FGF23 median serum levels was significantly higher in patients than in diabetic controls [67.7 (59.5–77.8) pg/mL and 43.89 (37.5–50.4), P < 0.001] and was significantly and independently associated with unstable plaque in patients with internal carotid artery stenosis [OR, 5,71 (95 % CI, 2.09–15.29].ConclusionsWe have found, for the first time, that FGF23 could be associated with unstable plaque in type 2 diabetic patients with internal carotid artery stenosis.

Highlights

The object of this study was to investigate the potential role of fibroblast growth factor 23 (FGF23) on plaque stability in type 2 diabetic patients with internal carotid artery stenosis
The present study evaluated whether serum FGF23 level is associated with internal carotid artery stenosis, defined as high-grade (>70 %) carotid stenosis (ICAS), and with carotid plaque stability and correlates with other inflammatory cytokines [High-Sensitivity C-reactive protein (Hs-CRP) and interleukin-6 (IL-6)]
Study Population We studied 361 consecutive Type 2 diabetes (T2D) patients, with ICAS who underwent a carotid endarterectomy, recruited among subjects consecutively admitted to the Department of Vascular Surgery at the A

Summary

Introduction

The object of this study was to investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis. FGF23, a hormone secreted primarily by osteocytes and to a lesser extent by osteoblasts, is involved in the regulation of vitamin D metabolism, phosphorus homeostasis and bone mineralization. It inhibits activation of calcitriol [1,25(OH)2D], induces urinary phosphorous excretion and suppresses parathyroid hormone (PTH) synthesis [3,4,5]. The present study evaluated whether serum FGF23 level is associated with internal carotid artery stenosis, defined as high-grade (>70 %) carotid stenosis (ICAS), and with carotid plaque stability and correlates with other inflammatory cytokines [High-Sensitivity C-reactive protein (Hs-CRP) and interleukin-6 (IL-6)]. We included osteoprotegerin (OPG) levels in analyzing the possible association of FGF23 with unstable plaque

Methods

Results

Conclusion