Abstract

Fibroblast growth factor 21 (FGF21) is a key regulator in glucose and lipid metabolism and its plasma levels have been shown to be increased not only in humans in different situations such as type 2 diabetes, obesity, and nonalcoholic fatty liver disease but also in animal models of sepsis and pancreatitis. FGF21 is considered as a pharmacological candidate in conditions associated with insulin resistance. The aim of this study was to compare FGF21 plasma levels in patients with sepsis, in patients with systemic inflammatory response syndrome (SIRS), and in healthy controls. We measured FGF21 plasma concentrations in 22 patients with established sepsis, in 11 with SIRS, and in 12 healthy volunteers. Here, we show that FGF21 levels were significantly higher in plasma obtained from patients with sepsis and SIRS in comparison with healthy controls. Also, FGF21 levels were significantly higher in patients with sepsis than in those with noninfectious SIRS. FGF21 plasma levels measured at study entry correlated positively with the APACHE II score, but not with procalcitonin levels, nor with C-reactive protein, classical markers of sepsis. Plasma concentrations of FGF21 peaked near the onset of shock and rapidly decreased with clinical improvement. Taken together, these results indicate that circulating levels of FGF21 are increased in patients presenting with sepsis and SIRS, and suggest a role for FGF21 in inflammation. Further studies are needed to explore the potential role of FGF21 in sepsis as a potential therapeutic target.

Highlights

  • Fibroblast growth factor 21 (FGF21) is a member of the FGF superfamily, consisting of FGF19, FGF21, and FGF23 (1, 2, 3, 4)

  • Sepsis is accompanied by glucose and lipid alterations, and FGF21 is considered as a key regulator in glucose and lipid metabolism (1, 6, 7, 8, 11)

  • FGF21 plasma levels are increased in type 2 diabetes, obesity, nonalcoholic fatty liver disease (NAFLD) and dyslipidemia (35, 36, 37, 38, 39), but injection of FGF21 in animal models of insulin resistance has been shown to improve this condition (9, 10, 11, 13, 14)

Read more

Summary

Introduction

Fibroblast growth factor 21 (FGF21) is a member of the FGF superfamily, consisting of FGF19, FGF21, and FGF23 (1, 2, 3, 4). Because they lack the conventional FGF-heparinbinding domain, these FGFs can escape the body’s vast deposition of heparansulfate proteoglycans and can be released into the circulation and function as endocrine factors (5). FGF21 may have a potential role as a therapeutic agent for conditions associated with insulin resistance as it has been shown that administration of a recombinant form of this hormone in obese mice and diabetic monkeys improves insulin sensitivity, body weight, and lipid profile (9, 10, 11, 12, 13, 14).

Objectives
Methods
Results
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call